Experimental models for pre-clinical and translational investigation

In vitro (patient-derived cells, iPSCs, organoids, co-culture systems, etc) and in vivo models (mice, chicken embryo) have been developed to provide reliable tools for cellular and gene therapy product evaluation and optimization. Selection of models, as well as preclinical and clinical development expertises are provided to define the most adapted evidence-generation plan for identification and validation of new CAR cell targets, impact of the microenvironment, predictive biomarkers of response to treatment, etc.